3-chloro-5-hydroxybenzoic Acid

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

3-氯-5-羟基苯甲酸 (3-氯-5-羟基 BA) 是 GPR81 的激动剂 (EC50 : 16 μM)。

3-chloro-5-hydroxy Benzoic Acid (3-chloro-5-hydroxy BA) is an agonist of GPR81 (EC50 : 16 μM).

3-Chloro-5-hydroxybenzoic acid shows potency against human (EC50=16 μM), monkey (EC50=17 μM), dog (EC50=67 μM), rat (EC50=7 μM), mouse (EC50=22 μM), and hamster GPR81 (EC50=27 μM).

3-Chloro-5-hydroxybenzoic acid (30, 100, and 300 mg/kg; PO in overnight fasted C57Bl6/J mice fed high fat chow for 10 weeks) shows significant reductions in free fatty acids at all doses tested, resulting in a minimum efficacious dose of 30 mg/kg.Pharmacokinetic Parameters of 3-Chloro-5-hydroxybenzoic acid in Mice. Animal Model:C57Bl6/J mice (DIO mice)Dosage:30, 100, and 300 mg/kg Administration:PO in overnight fasted C57Bl6/J mice fed high fat chow for 10 weeks Result:Significant reductions in nonesterified free fatty acid cholesterol (NEFAc) at all doses tested.

——

Cell Cycle/DNA Damage

GPR

GPR81

——

——

53984-36-4

172.57

C7H5ClO3

>98% (HPLC)

DMSO:34mg/mL(197.03mM)

O=C(O)c1cc(O)cc(Cl)c1

5-Chloro-m-salicylic acid

(-20℃)

With Ice Pack

≥ 2 years